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- *****************************************************
- * Photosynthetic reaction center proteins signature *
- *****************************************************
-
- In the photosynthetic reaction center of purple bacteria, two homologous
- integral membrane proteins, L(ight) and M(edium), are known to be essential to
- the light-mediated water-splitting process. In the photosystem II of
- eukaryotic chloroplasts two related proteins are involved: the D1 (psbA) and
- D2 proteins (psbD). These four types of protein probably evolved from a
- common ancestor [see 1,2 for recent reviews].
-
- We developed a signature pattern which include two conserved histidine
- residues. In L and M chains, the first histidine is a ligand of the magnesium
- ion of the special pair bacteriochlorophyll, the second is a ligand of a
- ferrous non-heme iron atom. In photosystem II these two histidines are thought
- to play a similar role.
-
- -Consensus pattern: [NH]-x(4)-P-x-H-x(2)-[SAG]-x(11)-[SAGC]-x-H-[SAG](2)
- [The first H is a magnesium ligand]
- [The second H is a iron ligand]
- -Sequences known to belong to this class detected by the pattern: ALL, except
- for broad bean psbA which has Gln instead of the second His.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Expert(s) to contact by email: Edelman M.
- lpedel@weizmann.weizmann.ac.il
- Hirschberg J.
- hirschu@hujivms.huji.ac.il
-
- -Last update: June 1994 / Text revised.
-
- [ 1] Michel H., Deisenhofer J.
- Biochemistry 27:1-7(1988).
- [ 2] Barber J.
- Trends Biochem. Sci. 12:321-326(1987).
-